10X Genomics 01/2022 - Present

Senior Scientist, Applied Bioinformatics

A*STAR, Singapore 06/2020 - 01/2022

Postdoctoral Fellow (Computational Biology) in Genome Institute of Singapore

National University of Singapore, Singapore 01/2016 - 04/2020

Ph.D. (Computational Biology) in Cancer Science Institute of Singapore

Zhejiang University, Zhejiang, China 09/2010 – 06/2015

Bachelor of Medicine (National Base Class)

University of California, Los Angeles, the United States 2014

Bowen Zhu, Megan Finch-Edmondson, Kim Whye Leong, Xiaoqian Zhang, Mitheera V., Quy Xiao Xuan Lin, Yaelim Lee, Wei Ting Ng, Huili Guo, Yue Wan, Marius Sudol, Ramanuj DasGupta. LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer. Cell Death Discovery. doi:10.1038/s41420-021-00761-0

Florian Schmidt, Bobby Ranjan, Quy Xiao Xuan Lin, Vaidehi Krishnan, Ignasius Joanito, Mohammad Amin Honardoost, Zahid Nawaz, Prasanna Nori Venkatesh, Joanna Tan, Nirmala Arul Rayan, S.Tiong Ong, Shyam Prabhakar. RCA2: a scalable supervised clustering algorithm that reduces batch effects in scRNA-seq data. Nucleic Acids Research (2021). 10.1093/nar/gkab632

Xiaobei Luo, Eliza Li Shan Fong, Chaojun Zhu, Quy Xiao Xuan Lin, Man Xiong, Aimin Li, Tingting Li, Touati Benoukraf, Hanry Yu, Side Liu. Hydrogel-based colorectal cancer organoid co-culture models. Acta Biomaterialia (2020). 10.1016/j.actbio.2020.12.037.

Yanjing V. Liu, Mahmoud A. Bassal, Quy Xiao Xuan Lin, Chan-Shuo Wu, Junsu Kwon, Qiling Zhou, Hong Kee Tan, Alexander K. Ebralidze, Li Chai, Touati Benoukraf, Annalisa Di Ruscio, Daniel G. Tenen. Targeted intragenic demethylation initiates chromatin rewiring for gene activation. bioRxiv (2020). 2020.07.16.205922.

Yong Chun Chong, Tan Boon Toh, Zhiling Chan, Quy Xiao Xuan Lin, Lissa Hooi, Zhaobing Ding, Wai Ho Shuen, Han Chong Toh, Pierce Chow, Yulan Wang, Touati Benoukraf, Edward Kai-Hua Chow, Weiping Han. Targeted Inhibition of Purine Metabolism is Effective in Suppressing Hepatocellular Carcinoma Progression. Hepatology Communications (2020).

Quy Xiao Xuan Lin, Denis Thieffry, Sudhakar Jha, Touati Benoukraf. TFregulomeR reveals transcription factors’ context-specific features and functions. Nucleic Acids Research (2019). 10.1093/nar/gkz1088. (First author)

Quy Xiao Xuan Lin, Khadija Rebbani, Sudhakar Jha, Touati Benoukraf. ZBTB33 (Kaiso) methylated binding sites are associated with primed heterochromatin. bioRxiv (2019). 585653. (First author)

Chong Yang, Michihiro Hashimoto, Quy Xiao Xuan Lin, Darren Qiancheng Tan, Toshio Suda. Sphingosine-1-phosphate signaling modulates terminal erythroid differentiation through the regulation of mitophagy. Experimental Hematology (2019). 72:47–59.e1.

Quy Xiao Xuan Lin, Stephanie Sian, Omer An, Denis Thieffry, Sudhakar Jha and Touati Benoukraf. MethMotif: An integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles. Nucleic Acids Research (2018), 47 (D1), D145-D154. (First author)

Luqman Hakim Abdul Hadi*, Quy Xiao Xuan Lin*, Tran Minh Tri*, Marie Loh, Hong Kiat Ng, Agus Salim, Richie Soong and Touati Benoukraf. miREM: An expectation-maximization approach for prioritizing miRNAs associated with gene-sets. BMC Bioinformatics (2018), 19, 299. (* Co-first authors)

Eliza Li Shan Fong*, Tan Boon Toh*, Quy Xiao Xuan Lin#, Zheng Liu, Lissa Hooi, Masturah Bte Mohd Abdul Rashid, Touati Benoukraf, Edward Kai-Hua Chow, The Hung Huynh, Hanry Yu. Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer. Biomaterials (2018), 159, pp. 229-240. (* Co-first authors; # Second author)